Thermo Fisher Scientific CDK11 Polyclonal Antibody
CDK11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관. 세포 주기 조절 및 종양 억제 연구에 활용 가능.
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- A300311Ax (2개 옵션)
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 730 and the C-terminus (residue 780) of human Cell Division Cycle 2-like 2 (CDK11A/CDK11B). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Mouse.
Target Information
CDK11 is a member of the cyclin-dependent kinase 11 family, essential for eukaryotic cell cycle control. It is closely related to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 acts as a negative regulator of normal cell cycle progression, and its expression is regulated during murine embryogenesis. Its activity is coordinated with p34 (cdc2) during the cell cycle. CDK11 may contain tumor suppressor regions affected by chromosome 1p36 modifications in neuroblastoma and can be cleaved by caspases, playing roles in cell apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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