Thermo Fisher Scientific Aggrecan core protein 1 Polyclonal Antibody
Aggrecan core protein을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rabbit, Rat에 반응하며 Protein A로 정제된 고순도 항체입니다. 액상 형태로 -20°C에서 안정적으로 보관 가능합니다.
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Thermo Fisher Scientific Aggrecan core protein 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Aggrecan core protein (amino acids 101–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene. It is a key component of the extracellular matrix in cartilage, providing resistance to compression.
The human protein (~250 kDa, 2316 amino acids) exists in multiple isoforms due to alternative splicing and exhibits a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to its core.
Aggrecan degradation and synthesis are critical in cartilage deterioration related to joint injury, disease, and aging. It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Fragments of Aggrecan are released into synovial fluid during osteoarthritis progression due to cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 detect neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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