Thermo Fisher Scientific UBASH3A Monoclonal Antibody (OTI5B4), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized to both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain. TULA is expressed at high levels in thymus, bone marrow, spleen, and peripheral blood leukocytes. It exists as a homodimer or homo-oligomer, interfering with degradation of receptor-type tyrosine kinases and promoting accumulation of activated receptors on the cell surface. Additionally, TULA forms part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA maps to human chromosome 21 and may be involved in the pathogenesis of type I diabetes. Multiple isoforms are produced via alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.