Thermo Fisher Scientific GCNT7 Polyclonal Antibody
GCNT7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 고농도(1 mg/mL) 액상 형태, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GCNT7 (amino acids 241–430) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GCNT7 is a 430 amino acid glycosyltransferase localized to the Golgi apparatus. Members of this family include GCNT1, GCNT2, GCNT3, GCNT4, and GCNT6.
GCNT1 plays a regulatory role in mucin-type O-glycan biosynthesis, which serves as ligands in cell adhesion. In leukocytes, GCNT1 regulates synthesis of core 2 O-glycans carrying sialyl-Lewis x (sLex) oligosaccharides that enable high affinity binding to Selectin proteins.
Downregulation of Selectin ligand expression inhibits tissue infiltration, making glycosyltransferase 14 family members potential drug targets for inflammatory disorders and other pathologies involving Selectin proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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