Thermo Fisher Scientific Ubinuclein 1/2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-DNSEAYDELVPASLT, from the internal region of UBN1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ubinuclein 1/2,uniProtId:Q6ZU65-1,ncbiNodeId:9606,antigenRange:217-231,antigenLength:1347,antigenImageFileName:PA5-37942_Ubinuclein_12_Q6ZU65-1_Goat.svg,antigenImageFileNamePDP:PA5-37942_Ubinuclein_12_Q6ZU65-1_Goat_PDP.jpeg,sortOrder:1},{targetFamily:Ubinuclein 1/2,uniProtId:Q9NPG3-1,ncbiNodeId:9606,antigenRange:140-154,antigenLength:1134,antigenImageFileName:PA5-37942_Ubinuclein_12_Q9NPG3-1_Goat.svg,antigenImageFileNamePDP:PA5-37942_Ubinuclein_12_Q9NPG3-1_Goat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2554548

Product Specific Information

This antibody is predicted to react with mouse, rat, dog, pig, cow and zebrafish based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Target Information

Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.