Thermo Fisher Scientific NSFL1C Polyclonal Antibody
NSFL1C 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합합니다. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 4°C에서 보관하며 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 to 75 of human NSFL1 (p97) Cofactor (p47) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine, and Orangutan
Target Information
p47, also known as NSFL1C, UBX1, UBXD10, or UBXN2C, is a 370 amino acid protein localized to both the nucleus and Golgi apparatus (specifically Golgi stacks). It contains one SEP domain and one UBX domain.
p47 forms a ternary complex with VCP (involved in vesicle fusion) and Syntaxin 5, modulating VCP ATPase activity. It is essential for Golgi stack fragmentation during mitosis and reassembly afterward.
Phosphorylation during mitosis inhibits p47-Golgi interaction, ensuring proper Golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with mouse, indicating conserved function. Multiple isoforms exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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