Thermo Fisher Scientific Acetyl-CoA Carboxylase Polyclonal Antibody
Western blot, IHC, ICC/IF에 적합한 다클론 항체. 인간, 마우스, 랫트 반응성. 합성 펩타이드 면역원으로 제작. PBS/glycerol 용액 형태로 제공되며 -20°C 보관. ACC1 단백질의 내인성 발현 검출에 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ACACA (Accession Q13085), corresponding to amino acid residues L59–V109 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818480 |
Product Specific Information
Antibody detects endogenous levels of total ACC1.
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is regulated at both transcriptional and translational levels, and also through phosphorylation/dephosphorylation of serine residues and allosteric modulation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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