Thermo Fisher Scientific MCRS1 Polyclonal Antibody
MCRS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 고순도 항원 친화 크로마토그래피 정제 제품으로 인간, 마우스, 랫트 반응성. 연구용으로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MCRS1. Recombinant protein control fragment (Product #RP-97876) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643817 |
Product Specific Information
Immunogen sequence:
HPDAFYLART AKALQAHWQL MKQYYLLEDQ TVQPLPKGDQ VLNFSDAEDL IDDSKLKDMR DEVLEHELMV ADRRQKREIR QLEQELHKWQ VLVD
- Highest antigen sequence identity to orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
MCRS1 modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183).
As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852).
It is a putative regulatory component of the chromatin remodeling INO80 complex, involved in transcriptional regulation, DNA replication, and potentially DNA repair.
MCRS1 may also act as an inhibitor of TERT telomerase activity (PubMed:15044100).
It binds to G-quadruplex structures in mRNA and to RNA homopolymers poly(G) and poly(U) (PubMed:16571602).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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