Thermo Fisher Scientific MCRS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000-1:2,500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MCRS1. Recombinant protein control fragment (Product #RP-97876). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MCRS1,uniProtId:Q96EZ8-1,ncbiNodeId:9606,antigenRange:238-331,antigenLength:462,antigenImageFileName:PA5-58639_MCRS1_Q96EZ8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58639_MCRS1_Q96EZ8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643817

Product Specific Information

Immunogen sequence: HPDAFYLART AKALQAHWQL MKQYYLLEDQ TVQPLPKGDQ VLNFSDAEDL IDDSKLKDMR DEVLEHELMV ADRRQKREIR QLEQELHKWQ VLVD

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.