Thermo Fisher Scientific IL-6 Monoclonal Antibody (B-E8), FITC, eBioscience
인간 IL-6을 특이적으로 인식하는 단클론 항체로, FITC 형광 표지되어 Flow Cytometry에 최적화됨. IL-6 수용체 결합 억제 및 세포 증식 차단 기능. 고순도(>95%) 제품으로 연구용으로만 사용 가능.
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Thermo Fisher Scientific IL-6 Monoclonal Antibody (B-E8), FITC, eBioscience
Applications
- Flow Cytometry (Flow): Assay-Dependent
- Functional Assay (Functional): Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B-E8 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 10 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | TBS, pH 7.2–7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10609209 |
Product Specific Information
BMS130FI (B-E8) recognizes natural and recombinant forms of human Interleukin-6 with an affinity of 0.5 nM.
Inhibits IL-6 binding to its receptors and blocks Interleukin-6 induced proliferation on B9 cells.
Applications Tested: Flow Cytometry (Intracellular Staining).
Purity: >95%.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Target Information
IL-6 encodes a cytokine involved in inflammation and B cell maturation.
This protein acts as an endogenous pyrogen, inducing fever in autoimmune or infectious conditions.
It is primarily expressed at sites of acute and chronic inflammation, secreted into serum, and triggers inflammatory transcriptional responses through IL-6 receptor alpha.
IL-6 is implicated in diseases such as diabetes mellitus, systemic juvenile rheumatoid arthritis, Kaposi Sarcoma, and Rheumatoid Arthritis.
Elevated IL-6 levels have also been observed in viral infections, including COVID-19 (SARS-CoV-2).
Usage Notice
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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