Thermo Fisher Scientific GABBR1 Polyclonal Antibody
GABBR1 단백질을 인식하는 염소 유래 폴리클로날 항체로, 인간 시료에 반응합니다. IHC(P)에서 5–8 µg/mL 농도로 사용 가능하며, 비결합형 액상 형태입니다. TBS(pH 7.3) 버퍼에 0.5% BSA 및 0.02% sodium azide 포함, -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–8 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence: DRLSCDGSRVHLLYK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933089 |
Product Specific Information
- Recognizes reported isoforms a, b, and c (NP_001461.1, NP_068703.1, NP_068704.2).
- Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that:
- Inhibit adenylyl cyclase activity
- Stimulate phospholipase A2
- Activate potassium channels
- Inactivate voltage-dependent calcium channels
- Modulate inositol phospholipids hydrolysis
Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating inwardly rectifying potassium (Kir) channels.
Implications include synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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