Thermo Fisher Scientific LPIN1 Polyclonal Antibody
LPIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 1 mg/mL 농도. 지방대사 및 인슐린 감수성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 829–890 of Human Lipin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546180 |
Product Specific Information
- Recommended positive control: H1299
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, a conserved N-terminal (NLIP) domain, and a C-terminal (CLIP) domain.
LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It selectively activates PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of the nuclear receptor PPARA.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Overexpression promotes fat accumulation and insulin sensitivity, whereas deficiency can lead to insulin resistance and lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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