Thermo Fisher Scientific TPC2 Polyclonal Antibody
TPC2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간 시료에 반응. 합성 펩타이드 항원으로 제작되어 높은 특이성과 안정성을 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TPC2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 700–752 of human TPC2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at –20°C avoiding freeze/thaw cycles. Add glycerol (1:1) for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TPC2.
Target Information
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane.
It may also be involved in smooth muscle contraction.
The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain.
The Tpcn2 protein localizes to lysosomal membranes and enables NAADP-induced calcium ion release from lysosome-related stores.
Tpcn2 is ubiquitously expressed, with elevated expression in liver and kidney.
Two common nonsynonymous SNPs in Tpcn2 strongly associate with blond versus brown hair pigmentation.
Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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