Thermo Fisher Scientific ATXN7L3B Polyclonal Antibody
ATXN7L3B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(파라핀) 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 안정적인 액상 형태로 연구용 적합.
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Thermo Fisher Scientific ATXN7L3B Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ATXN7L3B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
By binding to ENY2, ATXN7L3B interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex, which includes ENY2, ATXN7, ATXN7L3, and USP22. It affects USP22 DUB activity toward histones indirectly by altering the subcellular distribution of ENY2 and its availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2, resulting in loss of nuclear ENY2-ATXN7L3 association and destabilization of ATXN7L3. Also influences protein expression levels of ENY2 and ATXN7L3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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