Thermo Fisher Scientific RNF216 Polyclonal Antibody
RNF216 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피로 정제된 액상 항체. 4°C에서 보관하며 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 775 to 825 of Human Ring Finger Protein 216 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88.
Several regulatory mechanisms control TLR signal transduction, including inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR.
Another mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A (RING finger protein) binds to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing their ubiquitization.
Overexpression of TRIAD3A promotes degradation of TLR4 and TLR9, reducing ligand-specific activation, while depletion enhances TLR activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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