Thermo Fisher Scientific TNFAIP8 Monoclonal Antibody (OTI1H9), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2, or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF.
Its induction by TNF depends on NFkappa B activation. TNFalpha-IP 8 negatively mediates apoptosis and may play a role in tumor progression. It specifically inhibits caspase-8 activity, preventing BID cleavage and caspase-3 activation during TNF-mediated apoptosis.
TNFalpha-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney. It exists as three isoforms produced by alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.