Thermo Fisher Scientific CD357 (AITR/GITR) Polyclonal Antibody
CD357 (AITR/GITR) 폴리클로날 항체로 인간 TNFRSF18 단백질을 인식합니다. Western blot 및 IHC에 사용 가능하며, 면역관용 및 T세포 활성 조절 연구에 적합합니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human TNFRSF18 (aa 192–241) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2576304 |
Product Specific Information
- Peptide sequence: LRSQCMWPRE TQLLLEVPPS TEDARSCQFP EEERGERSAE EKGRLGDLWV
- Sequence homology: Human: 100%
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is a protein encoded by the TNFRSF18 gene located at 1p36.33. It belongs to the TNF-receptor superfamily and is upregulated upon T-cell activation. This receptor plays a key role in maintaining immunological self-tolerance mediated by CD25(+)CD4(+) regulatory T cells. Mouse knockout studies indicate its involvement in CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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