Thermo Fisher Scientific Human NLRP3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent
• Reference: [#references-component-id]

Blocking Assay (BLOCK)

• Assay-dependent
• Reference: [#references-component-id]

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the amino terminus of human NALP3.
PEP-0952 can be used as a blocking peptide with polyclonal antibody PA5-20838.

Target Information

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex.
This complex functions as an upstream activator of NF-kappaB signaling and plays a role in the regulation of inflammation, immune response, and apoptosis.
Mutations in this gene are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5′ UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5′ UTR splice patterns are biologically valid.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.