Thermo Fisher Scientific ITGA2 Monoclonal Antibody (DX5), Biotin
Mouse-reactive monoclonal antibody (clone DX5) targeting CD49b (Integrin alpha 2), conjugated with Biotin. Suitable for flow cytometry. Purified IgM rat antibody, supplied in PBS buffer with sodium azide. For research use only.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DX5 |
| Immunogen | RIL-2-propagated NK1.1 cells from C57BL/6 mice |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534432 |
Additional Formats
Target Information
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a 150 kD glycoprotein that complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (α2β1, GPIa/IIa) complex.
VLA-2 acts as an extracellular receptor for laminin, collagen, and fibronectin, triggering intracellular signaling upon ligand interaction.
It plays roles in VEGF-induced angiogenesis, adhesion, and lymphocyte activation.
CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, epithelial cells, and subsets of T and B cells, including CD4⁺ Tr1 cells co-expressing LAG-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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