Thermo Fisher Scientific MCAM Monoclonal Antibody (OTI3D1), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and in various normal and malignant cell types.
CD146 functions as a calcium-independent cell adhesion molecule and participates in signal transduction involving Fyn kinase and tyrosine phosphorylation of proteins related to actin cytoskeleton assembly.
It plays a role in endothelial cell cohesion, tumor cell interaction with vascular elements, and neural crest cell adhesion during embryonic development.
CD146 acts as a surface receptor triggering phosphorylation of FYN and PTK2, and transiently increases intracellular calcium concentration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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