Thermo Fisher Scientific MCAM Monoclonal Antibody (OTI3D1), TrueMAB
인간 MCAM(CD146)을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능합니다. 세포 접착 및 신호전달 연구용으로 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D1 |
| Immunogen | Full length human recombinant protein of human MCAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell-cell junctions in endothelial cells and in various normal and malignant cell types.
CD146 functions as a calcium-independent cell adhesion molecule and participates in signal transduction involving Fyn kinase and tyrosine phosphorylation of proteins related to actin cytoskeleton assembly.
It plays a role in endothelial cell cohesion, tumor cell interaction with vascular elements, and neural crest cell adhesion during embryonic development.
CD146 acts as a surface receptor triggering phosphorylation of FYN and PTK2, and transiently increases intracellular calcium concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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