Thermo Fisher Scientific Human BRE Synthetic Peptide
Human BRCC45 아미노 말단 18개 서열에 대응하는 합성 펩타이드로, 항체 PA5-20415의 차단 펩타이드로 사용 가능. 인간 반응성, 액상 형태, 200 µg/mL 농도, PBS 버퍼에 0.1% BSA 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human BRCC45.
PEP-0532 can be used as a blocking peptide with polyclonal antibody PA5-20415.
Target Information
BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage.
BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway.
Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed.
At least three isoforms of BRCC45 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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