Thermo Fisher Scientific FAM193B Polyclonal Antibody
Human FAM193B 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 용액에 보존. 연구용으로만 사용 가능.
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Thermo Fisher Scientific FAM193B Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAM193B (Product #RP-94989) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2641354 |
Product Specific Information
Immunogen sequence:
NSTEPKVPNS ARAAKRARHK LKKKEKEKAQ LAAEALKQAN RVSGSREPRP ARERLLEWPD RELDRVNSFL SSRLQEIKNT VKDSIRASFS VCE
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 87%
Target Information
FAM193B (also known as IRIZIO) was initially identified as a protein upregulated in alveolar rhabdomyosarcoma (ARMS), a fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with FOXO1.
It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis.
In PAX3-FOXO1-expressing primary mouse fibroblasts with a defective p53 pathway, FAM193B expression enabled tumorigenic transformation, suggesting FAM193B may contribute to rhabdomyosarcomagenesis in humans.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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