Thermo Fisher Scientific BMP-2 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Dog: 100%
Horse: 100%
Pig: 100%
Rat: 100%

Target Information

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998, Francis-West et al. 1999).
Mature BMPs are 30–38 kDa proteins that assume a TGF-beta-like cysteine knot configuration.
Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999).
BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997).
BMPs may also play roles in development of the viscera, influencing cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999).
Like TGF-beta, BMPs bind to a type II receptor, which recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.