Thermo Fisher Scientific Cyclin B1/CCNB1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Cyclin B1 (CCNB1). Suitable for Western blot and immunoprecipitation. Liquid form, 1 mg/mL concentration. Predicted cross-reactivity with primates. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of human G2/mitotic-specific cyclin-B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, and Chimpanzee
Target Information
Cyclins bind to and regulate the activity of cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and is essential for controlling the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF).
Two alternative transcripts exist: one constitutively expressed and another cell cycle-regulated, predominantly during G2/M phase. Cyclin B1 accumulates steadily during G2 phase and is abruptly degraded at the end of mitosis via APC-dependent destruction.
Overexpression of Cyclin B1 has been observed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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