Thermo Fisher Scientific MACROD1 Polyclonal Antibody
Thermo Fisher Scientific의 MACROD1 폴리클로날 항체는 인간 단백질 MACROD1을 특이적으로 인식합니다. ICC/IF에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 장기 보관 시 -20°C를 권장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MACROD1. Recombinant protein control fragment (Product #RP-107790) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664561 |
Product Specific Information
- Immunogen sequence: AEIVLATLREW LEQHKDKVDR LIICVFLEKD EDIYRSRLPH YFPVA
- Highest antigen sequence identity to the following orthologs: mouse 91%, rat 91%
Target Information
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose.
Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.
Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen.
May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation.
Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction.
Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells.
Enhances ESR1-mediated transcription activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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