Thermo Fisher Scientific PTOP Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal Antibody로 다양한 응용(ELISA, WB, IHC, ICC/IF)에 사용 가능. KLH 결합 합성 펩타이드(aa 121–210)로 면역화. Protein A로 정제된 액상 형태, 1 mg/mL 농도. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human PTOP, amino acids 121–210 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway.
The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase, which converts orotic acid to orotidine-5'-monophosphate.
The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase, which converts orotidine-5'-monophosphate to uridine monophosphate.
Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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