Thermo Fisher Scientific DMAP1 Monoclonal Antibody (5H4)

Thermo Fisher Scientific DMAP1 Monoclonal Antibody (5H4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MATGADVRDI LELGGPEGDA ASGTISKKDI INPDKKKSKK SSETLTFKRP EGMHREVYAL LYSDKKDAPP LLPSDTGQGY RTVKAKLGSK KVRPWKWMPF

Target Information

DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription.
The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1.
During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication.
The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription.
DMAP1 is a component of the nucleosome acetyltransferase of H4 complex and interacts with transcriptional corepressor tumor susceptibility gene 101 and pro-apoptotic death-associated protein 6.
DMAP1 is found in a wide variety of organisms from yeasts to humans.
The human DMAP1 gene is localized on chromosome 1p34.

Usage Note

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.