Thermo Fisher Scientific CRX Polyclonal Antibody
CRX 단백질을 표적으로 하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 검증 완료. 인간 CRX에 100% 반응성을 보이며, 광수용체 관련 유전자 연구에 적합. 액상 형태로 제공되며 -20°C에서 보관.
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Thermo Fisher Scientific CRX Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human CRX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610297 |
Product Specific Information
- Peptide sequence: VDLMHQAVPY PSPPLALDPP RRQRQERTVY TESQQKVLEF YFQKDQYPNY
- Sequence homology: Human: 100%
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin.
CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes and is also expressed in pinealocytes of the pineal gland, regulating melatonin synthesis gene expression and circadian activity.
Mutations in the CRX gene are associated with visual disorders such as cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP).
All known CRX mutations cause disease in heterozygotes, with missense mutations affecting the homeobox domain and frameshift mutations affecting the OTX domain.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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