Thermo Fisher Scientific ZNRF1 Polyclonal Antibody
Thermo Fisher Scientific의 ZNRF1 Polyclonal Antibody는 인간 ZNRF1 단백질 N-말단 펩타이드에 특이적으로 반응하는 토끼 유래 IgG 항체입니다. Western blot에 최적화되어 있으며, 신경세포 분화 및 신경전달 유지 연구에 적합합니다. 액상형으로 제공되며 -20°C 보관이 권장됩니다.
- 카탈로그번호
- PA569035
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ZNRF1 Polyclonal Antibody
Applications
- Western Blot (WB): 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human ZNRF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688803 |
Product Specific Information
This target displays homology in the following species:
Cow: 100% | Guinea Pig: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 86%
Target Information
ZNRF1 is an E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, playing a role in neuron cell differentiation. It contributes to neuronal transmission and plasticity, regulates Schwann cell differentiation, and promotes neurodegeneration by mediating Lys-48-linked polyubiquitination and subsequent degradation of AKT1 in axons. Degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to activation of GSK3B and phosphorylation of DPYSL2/CRMP2, which destabilizes microtubule assembly in axons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(원본 페이지의 항원 구조 이미지 및 PDP 이미지 포함)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.