Thermo Fisher Scientific GPR125 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GPR125. Recombinant protein control fragment (Product #RP-89573). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GPR125,uniProtId:Q8IWK6-1,ncbiNodeId:9606,antigenRange:147-283,antigenLength:1321,antigenImageFileName:PA5-52626_GPR125_Q8IWK6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52626_GPR125_Q8IWK6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642162

Product Specific Information

Immunogen sequence: DIFRGLTNLV RLNLSGNLFS SLSQGTFDYL ASLRSLEFQT EYLLCDCNIL WMHRWVKEKN ITVRDTRCVY PKSLQAQPVT GVKQELLTCD PPLELPSFYM TPSHRQVVFE GDSLPFQCMA SYIDQDMQVL WYQDGRI

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Target Information

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.