Thermo Fisher Scientific NOC3L Polyclonal Antibody
Thermo Fisher Scientific의 NOC3L Polyclonal Antibody는 인간 NOC3L 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer(40% glycerol)로 보관되며 연구용으로 사용됩니다.
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- PA566939
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human NOC3L. Recombinant protein control fragment (Product #RP-105433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664211 |
Product Specific Information
Immunogen sequence:
DDLQLMKDLGQ RVSFLTRDLS SSEPVHAKKR KHERIIDKYE KIPRTLQTAP EKELIHLLPI KDKSGIIPQT REKPV
Highest antigen sequence identity to the following orthologs: mouse 89%, rat 89%.
Target Information
GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by various cellular stresses, including nutrient deprivation and metabolic perturbations. It functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct dimers away from classical C/EBP binding sites, recognizing instead unique nonclassical sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells.
GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L, and NOC4L. NOC3L, also designated factor for adipocyte differentiation 24 (Fad24), promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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