Thermo Fisher Scientific DYNC1I2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human DYNC1I2 protein. Validated for WB, IHC(P), and ICC/IF applications. Affinity-purified, supplied in PBS with 40% glycerol. Suitable for research use in dynein-related cellular transport studies.
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- PA559226
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DYNC1I2. Recombinant protein control fragment (Product #RP-102895). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640845 |
Product Specific Information
Immunogen sequence:
HSDSDLGRGP IKLGMAKITQ VDFPPREIVT YTKETQTPVM AQPKEDEEE
Highest antigen sequence identity to orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into mechanical energy. Cytoplasmic or axonemal Dynein heavy, intermediate, light, and light-intermediate chains are components of minus end-directed motors that transport cellular cargos toward the cell center.
Axonemal Dynein motors contain one to three non-identical heavy chains and drive microtubule sliding in cilia and flagella, enabling motility. Cytoplasmic Dynein is a ~12-subunit complex including heavy, intermediate, and light chains, essential for organelle transport and centrosome assembly.
The carboxy-terminus is conserved and critical for motility, while amino-terminal regions vary. Dynein activity is regulated by proteins such as Dynactin, LIS1, and Nudel (NudE-like).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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