Thermo Fisher Scientific IRF7 Polyclonal Antibody
IRF7 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 면역세포염색에 적합하며, 인간에 반응. 항원 친화 크로마토그래피로 정제, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IRF7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.32 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792863 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Rhesus Monkey (91%).
- Positive Control: Jurkat, Raji, NCI-H929.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Interferons (IFNs) are involved in multiple immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors including IFN regulatory factor-3 (IRF3), which can stimulate transcription of IFN-α/β genes.
IRF7 is involved in transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a major role in the innate immune pathway by interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their functions have not been clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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