Thermo Fisher Scientific p400 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human p400. Recombinant protein control fragment (Product #RP-91695). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:p400,uniProtId:Q96L91-1,ncbiNodeId:9606,antigenRange:946-1086,antigenLength:3159,antigenImageFileName:PA5-53475_p400_Q96L91-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53475_p400_Q96L91-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645144

Product Specific Information

Immunogen sequence: DDEVDDEEET IEEEEANEGV VDHQTELSNL AKEAELPLLD LMKLYEGAFL PSSQWPRPKP DGEDTSGEED ADDCPGDRES RKDLVLIDSL FIMDQFKAAE RMNIGKPNAK DIADVTAVAE AILPKGSARV TTSVKFNAPS L

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.

Target Information

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.