Thermo Fisher Scientific Cathepsin D (Tumor Marker) Monoclonal Antibody (CTSD/4497)
Cathepsin D 단백질을 인식하는 단클론 항체로, Western blot 및 IHC 등 다양한 응용에 적합. 인간 시료 반응성, Mouse IgG1 아이소타입. 단백질 분해 및 종양 표지 연구용. 안정성 24개월, 4°C 보관.
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- 1509-MSM7-P1
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CTSD/4497 |
| Immunogen | Purified His-tagged CTSD protein (amino acids 104–250 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: MCF-7, A431, or SK-BR3 cells; kidney, liver, lung, or breast tissues.
- Cellular Localization: Cytoplasm
Specificity Comments:
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in protein degradation. It is synthesized as an inactive 43 kDa preprocathepsin D, which is cleaved and glycosylated to form a 46 kDa procathepsin D, and further processed into 28 kDa and 15 kDa subunits (heavy and light chains). Cathepsin D exhibits pepsin-like activity, contributing to protein turnover and proteolytic activation of hormones and growth factors. Mutations in this gene are linked to neuronal ceroid lipofuscinosis-10 and may be associated with diseases such as breast cancer and Alzheimer’s disease.
Target Information
Cathepsin D has been implicated in malignant tumor progression and prognosis of various human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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