Thermo Fisher Scientific Cathepsin D (Tumor Marker) Monoclonal Antibody (CTSD/4497)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Peptide Array (Array)

Assay-dependent

-

Immunoelectrophoresis (IE)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

CTSD/4497

Immunogen

Purified His-tagged CTSD protein. The antigen corresponds to amino acid range 104-250 of the target protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cathepsin D,uniProtId:P07339-1,ncbiNodeId:9606,antigenRange:104-250,antigenLength:412,antigenImageFileName:1509-MSM7-P1_Cathepsin_D_P07339-1_House_mouse.svg,antigenImageFileNamePDP:1509-MSM7-P1_Cathepsin_D_P07339-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is stable for 24 months.

Positive Control: MCF-7, A431 or SK-BR3 cells. Kidney, liver, lung or breast. Cellular Localization: Cytoplasm

Specificity Comments: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimers disease.

Target Information

Cathepsin D has been reported to be involved in malignant tumor progression and with prognosis of various human cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.