Thermo Fisher Scientific ARHGAP20 Polyclonal Antibody
ARHGAP20 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 안정적인 액상 형태로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human ARHGAP20, amino acids 1001–1191 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ARHGAP20 is a potent GTPase-activating protein (GAP) that converts Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain, and two Annexin-like (ANXL) repeats.
ARHGAP20 acts as a downstream target of Rap1, promoting neurite outgrowth through Rho inactivation in a Rap1-dependent manner. It functions as a tumor suppressor gene, often inactivated by deletion in breast cancer or by chromosomal translocation in B-cell chronic lymphocytic leukemia.
Reports suggest its involvement in cytoskeletal rearrangements and cell signaling during spermatogenesis. It is predominantly expressed in human brain, liver, ovary, and spinal cord, with lower expression in lymph nodes and fetal liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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