Thermo Fisher Scientific Importin 11/IPO11 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin. The complex is translocated through the pore by an energy-dependent, Ran-mediated mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, causing dissociation of the importin/substrate complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is maintained by asymmetric distribution of GTP- and GDP-bound Ran between cytoplasm and nucleus. IPO11 mediates nuclear import of UBE2E3 and RPL12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지