Thermo Fisher Scientific Importin 11/IPO11 Polyclonal Antibody
Rabbit polyclonal antibody against human Importin 11 (IPO11). Validated for Western blot and immunoprecipitation. Unconjugated, liquid form at 1 mg/mL concentration. For research use only, not for diagnostic or resale purposes.
- 카탈로그번호
- A304811Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Importin 11/IPO11 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 925–975 of human Importin-11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as a receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin. The complex is translocated through the pore by an energy-dependent, Ran-mediated mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, causing dissociation of the importin/substrate complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is maintained by asymmetric distribution of GTP- and GDP-bound Ran between cytoplasm and nucleus. IPO11 mediates nuclear import of UBE2E3 and RPL12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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