Thermo Fisher Scientific p53R2 Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 p53R2 Polyclonal Antibody. Western blot 및 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제된 Rabbit IgG 항체로, 1 mg/mL 농도의 액상 형태. DNA 손상 복구 관련 p53 신호전달 연구에 적합.
- 카탈로그번호
- PA529009
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–351 of Human p53R2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546485 |
Product Specific Information
- Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse brain
- Predicted reactivity: Mouse (93%), Rat (94%), Xenopus laevis (81%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.
p53R2 is a p53-inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. It is induced by ultraviolet and gamma irradiation that cause DNA damage. The product of the p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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