Thermo Fisher Scientific p53R2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, mouse brain
• Predicted reactivity: Mouse (93%), Rat (94%), Xenopus laevis (81%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered.
p53R2 is a p53-inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. It is induced by ultraviolet and gamma irradiation that cause DNA damage. The product of the p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.