Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI7F5), TrueMAB
LPIN1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot 및 IHC(P) 검증 완료. 인간 시료 반응성. 동결건조 형태, PBS 버퍼에 trehalose 포함. 지방 대사 및 인슐린 감수성 연구에 적합한 연구용 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7F5 |
| Immunogen | Full-length human recombinant protein of human LPIN1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, a conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) plays a critical role in adipose tissue development and metabolism. It activates PGC-1A target pathways such as fatty acid oxidation and mitochondrial oxidative phosphorylation through induction of PPARA expression.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Overexpression of LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency leads to insulin resistance and lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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