Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI7F5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, a conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) plays a critical role in adipose tissue development and metabolism. It activates PGC-1A target pathways such as fatty acid oxidation and mitochondrial oxidative phosphorylation through induction of PPARA expression.
LPIN1 also suppresses lipogenesis and circulating lipid levels. Overexpression of LPIN1 promotes fat accumulation and insulin sensitivity, while deficiency leads to insulin resistance and lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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