Thermo Fisher Scientific Kalirin Polyclonal Antibody
Kalirin 단백질을 표적으로 하는 Thermo Fisher Scientific의 산양 유래 폴리클로날 항체. Western blot, IHC, Flow cytometry, RIP 등 다양한 응용에 적합. 고순도 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–5 µg/mL | - |
| Flow Cytometry (Flow) | 10 µg/mL | - |
| RNA Immunoprecipitation (RIP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RWHLGPGDPFSTYV) corresponding to the C-terminus amino acids of KALRN (aa 1641–1654). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984802 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
HAP1 (huntingtin-associated protein 1) binds to huntingtin, a protein containing a polyglutamine region. When the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind huntingtin is enhanced by an expanded polyglutamine repeat region.
HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. It is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures, and budding vesicles in neurons.
Duo, also designated huntingtin-associated protein interacting protein (HAPIP), binds HAP1 and may have a role in vesicle trafficking and cytoskeletal function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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