Thermo Fisher Scientific Precerebellin Polyclonal Antibody
Precerebellin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 최적화됨. Human, Mouse, Rat 시료 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 2–8°C 보관 권장. 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid synthetic peptide from near the carboxy-terminus of human precerebellin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153695 |
Product Specific Information
- A suggested positive control is 293 cell lysate.
- PA5-20159 can be used with blocking peptide PEP-0278.
Target Information
Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway and indirectly enhances adrenocortical secretion in vivo through a paracrine mechanism involving medullary catecholamine release.
The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells and in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin possesses additional functions beyond those already described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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