Thermo Fisher Scientific UBASH3A Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 396-464. Recombinant protein control fragment (Product #RP-109879). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UBASH3A,uniProtId:P57075-1,ncbiNodeId:9606,antigenRange:396-464,antigenLength:661,antigenImageFileName:PA5-144832_UBASH3A_P57075-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144832_UBASH3A_P57075-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3091862

Product Specific Information

Immunogen sequence: KSVLVVRHGE RVDQIFGKAW LQQCSTPDGK YYRPDLNFPC SLPRRSRGIK DFENDPPLSS CGIFQSRIA

Antigen sequence identity: Mouse 84%; Rat 83%

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.