Thermo Fisher Scientific IL-12 p40 Polyclonal Antibody
Human IL-12 p40 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), Flow Cytometry에 적합. 고순도의 Protein A 및 항원 친화 크로마토그래피로 정제. PBS buffer에 0.09% sodium azide 함유, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 264–290 amino acids from the C-terminal region of human IL12B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541465 |
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells with broad biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa subunit encoded by this gene and a 35 kDa subunit encoded by IL12A.
This cytokine is expressed by activated macrophages and is essential for Th1 cell development and maintenance of memory/effector Th1 cells for long-term protection against intracellular pathogens.
Overexpression has been observed in the central nervous system of multiple sclerosis (MS) patients, suggesting a potential role in disease pathogenesis. Promoter polymorphisms have also been associated with asthma severity in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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