Thermo Fisher Scientific USP35 Polyclonal Antibody
Thermo Fisher Scientific의 USP35 폴리클로날 항체로 인간 USP35 단백질을 인식합니다. IHC(P) 및 ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 0.9 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용됩니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human USP35. Recombinant protein control fragment (Product #RP-101228). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649343 |
Product Specific Information
Immunogen sequence:
PPERCRRRRL GSVMRPTEDI TARELPPPTS AQGPGRVGPR RQRKHCITED TPPTSLYIEG LDSKEAGGQS SQEERIERE
Highest antigen sequence identity to the following orthologs:
- Mouse: 53%
- Rat: 58%
Target Information
p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence-specific DNA binding, interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage. Upon genotoxic stress (e.g., UV irradiation or DNA damage), p53 accumulates in the nucleus through post-translational modification. Activation of p53 can lead to cell cycle arrest or apoptosis, preventing proliferation of genetically damaged cells. Thus, p53-dependent pathways help maintain genomic stability by eliminating damaged cells. High levels of p53 accumulation can serve as a potential malignancy marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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