Thermo Fisher Scientific PXR Polyclonal Antibody
Human PXR 단백질을 인식하는 Goat Polyclonal Antibody로, WB, IHC, ChIP 등 다양한 응용에 적합. 0.5 mg/mL 농도의 액상형 제품으로 TBS 버퍼에 BSA 포함. 연구용으로 CYP3A4 전사 조절 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EQFAITLKSYIECNR) corresponding to internal amino acids of NR1I2 (aa 367–382) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979928 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4000.
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.
The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR.
It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codons, have been described for this gene.
Additional transcript variants exist, however, they have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-19080_PXR_O75469-1_Goat.svg, PA5-19080_PXR_O75469-1_Goat_PDP.jpeg)
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