Thermo Fisher Scientific Human Bit1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human Bit1.
PEP-0284 can be used as a blocking peptide with polyclonal antibody PA5-20167.

Target Information

The protein encoded by this gene is a mitochondrial protein with two putative domains: an N-terminal mitochondrial localization sequence and a UPF0099 domain.
In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce translation efficiency.
This protein also plays a role in regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix.
Mutations in this gene are associated with intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.