Thermo Fisher Scientific Sorcin Polyclonal Antibody
Sorcin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. 인간 및 생쥐 반응성 확인. 항원 친화 크로마토그래피로 정제된 고순도 항체. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Sorcin. Recombinant protein control fragment (Product #RP-104564) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662771 |
Product Specific Information
Immunogen sequence:
GGGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID ADELQRCLTQ SGIAGGYK
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 95%
Target Information
Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium-binding proteins and contains four EF-hand calcium-binding motifs. Human Sorcin shares 95% sequence identity with hamster Sorcin. It associates with sarcolemmal proteins such as Annexin VII, cardiac ryanodine receptors, and L-type Ca²⁺ channels, influencing intracellular Ca²⁺ homeostasis. Sorcin regulates intracellular Ca²⁺ cycling and influx pathways in cardiac and skeletal muscle during excitation-contraction. It is overproduced in many multidrug resistance (MDR) cells and regulates apoptosis pathways, serving as a marker for AML prognosis and a target for anti-MDR drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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