Thermo Fisher Scientific TMEM184C Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:2,500-1:5,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TMEM184C. Recombinant protein control fragment (Product #RP-101430). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM184C,uniProtId:Q9NVA4-1,ncbiNodeId:9606,antigenRange:376-437,antigenLength:438,antigenImageFileName:PA5-62896_TMEM184C_Q9NVA4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62896_TMEM184C_Q9NVA4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648623

Product Specific Information

Immunogen sequence: LSSSSQDAIS IASSMPPSPM GHYQGFGHTV TPQTTPTTAK ISDEILSDTI GEKKEPSDKS VD

Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 40%.

Target Information

Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.