Thermo Fisher Scientific Progesterone Receptor Polyclonal Antibody, Biotin
Progesterone receptor를 인식하는 Biotin 결합 rabbit polyclonal antibody로, WB, ELISA, IP에 사용 가능. 인간, 고양이, 돼지 등 다양한 종에 반응하며, 합성 펩타이드(aa 320-370)로 면역화됨. 고순도 Affinity chromatography 정제, 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 320–370 of human Progesterone Receptor protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B) due to alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for activating genes related to endometrium maintenance, pregnancy, and ovulation inhibition.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex including heat shock proteins and immunophilins. Upon progesterone binding, conformational change enables dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene leads to pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PGR-101-BIOTIN_Progesterone_Receptor_P06401-1_Rabbit.svg, PGR-101-BIOTIN_Progesterone_Receptor_P06401-1_Rabbit_PDP.jpeg)
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