Thermo Fisher Scientific ITIH4 Polyclonal Antibody
Human ITIH4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등에 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 기반 보관용액에 40% glycerol 포함, 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific ITIH4 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITIH4. Recombinant protein control fragment (Product #RP-100488) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642819 |
Product Specific Information
Immunogen sequence:
QGVEVTGQYE REKAGFSWIE VTFKNPLVWV HASPEHVVVT RNRRSSAYKW KETLFSVMPG LKMTMDKTGL LLLSDPDKVT IGLLFWDGRG EGLRLLLRDT DRFSSHVGGT LGQFYQEVLW GSPAASDDGR RTLRVQGNDH
- Highest antigen sequence identity to the following orthologs:
- Mouse: 59%
- Rat: 60%
Target Information
The inter-alpha-trypsin inhibitor (ITI, I-alpha-I) family is a classic example of protein-glycosaminoglycoprotein (PGP) complexes. These proteins occur constitutively in plasma at relatively high concentrations and result from alternating combinations of three kinds of heavy chains with a common light chain called the bikunin proteoglycan.
Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays inhibitory activity against trypsin, leukocyte elastase, and plasmin.
The heavy chains do not have protease inhibitory properties but can interact with hyaluronic acid, promoting extracellular matrix stability. The ITI protein family is suspected of playing a key role in extracellular matrix biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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