Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI4A4), TrueMAB
인간 CD20(MS4A1)에 특이적인 단클론 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 마우스 IgG1 형으로, 액상 상태이며 1 mg/mL 농도입니다. 연구용으로 B세포 표지 및 면역학 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A4 |
| Immunogen | Full-length human recombinant protein of human MS4A1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa, depending on phosphorylation. It is expressed on mature and most malignant B cells, as well as in a subset of T lymphocytes and follicular dendritic cells. CD20 expression correlates with surface IgM and regulates calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 is associated with lipid rafts, with the strength of this association influenced by extracellular signals and conformational changes. Upon receptor ligation, CD20 and BCR colocalize transiently before BCR endocytosis, while CD20 remains on the cell surface. CD20 is a key target for antibody-mediated B-cell depletion therapies since it is highly expressed on B-cell malignancies and remains membrane-bound after treatment.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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